12 Natural Alternatives to Oral Ivermectin Evidence based Review (2024) Part 4 of 4
11. Nattokinase - Anti Coagulant
Nattokinase (NK) is an enzyme derived from a traditional Japanese food called natto, and it is thought to help lower cholesterol, reduce inflammation, and improve circulation.
Nattokinase for Blood Clots
Nattokinase dissolves blood clots by directly hydrolyzing fibrin and plasmin substrate. It converts endogenous prourokinase to urokinase (uPA). It also degrades plasminogen activator inhibitor (PAI-1) and increases the level of tissue plasminogen activator (t-PA). (Source)
Tanikawa et al. (2022) examined the effect of nattokinase on the COVID-19 spike protein. In the first experiment, they demonstrated that spike was degraded in a time and dose-dependent manner in a cell lysate preparation that could be similar to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2 infected cells. This was reproduced in a similar study done by Oba and colleagues in 2021.
Nattokinase dissolves blood clots by directly hydrolyzing fibrin and plasmin substrate. It converts endogenous prourokinase to urokinase (uPA). It also degrades plasminogen activator inhibitor (PAI-1) and increases the level of tissue plasminogen activator (t-PA). (Source)
Human trials have demonstrated that NattoKinase (NK) provides support to the circulatory system by thinning the blood and dissolving blood clots. (Source, Source)
In a randomized controlled trial (2015), a single-dose of 2,000 FU NK (NSK-SD, Japan Bio Science Laboratory Co., Ltd) appears to potentiate thrombolysis and anti-coagulation profiles.
In another 8-week randomized controlled trial (2016), subjects were given 8 weeks supply of either a placebo or a nattokinase. Nattokinase NSK-SD® (subtilisin NAT) was encapsulated in veggie caps with 100 mg/capsule and standardized to at least 2,000 fibrinolytic units (FU) per each 100 mg daily oral dose. Subjects were instructed to take one capsule daily in the morning and to return the bottles with any remaining capsules at the 8-week visit.
The average level of vWF (Von Willebrand Factor) was reduced by 15% in the nattokinase group, whereas no consistent change was seen for the subjects consuming placebo for 8 weeks. The difference in vWF levels at 8 weeks between the two groups showed a statistical trend (P<0.09). This decrease in vWF levels was sex specific, as it was seen for the group of females consuming nattokinase (26% reduction, P<0.09) but not in the male group consuming nattokinase.
Dosage: Nattokinase 100 mg/day (equivalent to 2,000 fibrinolytic units [FU]), typically for a duration of 8 weeks, has been used in some studies evaluating thrombolytic/fibrinolytic and blood pressure effects.
12. Vitamin A
Summary results of more than 10 vitamin A and COVID-19 studies are available on this dedicated webpage: c19early.com/va.
Quercetin, Vitamin C, D, Zinc, Melatonin and the FLCCC Protocol
So how do we combine multiple nutrients together? Quercetin, Vitamin C, D, Zinc, Melatonin and Black Seed Oil are part of the FLCCC I-PREVENT and I-CARE protocols. For updated prevention and early outpatient protocol for COVID-19 positive, check out FLCCC I-MASK+ protocol.
Quercetin, zinc, vitamin D and C are also part of the Zelenko Protocol. In an effort to make it easier for patients, Dr Zelenko has developed an oral supplement that contains all four key ingredients: vitamin C, quercetin, vitamin D3 and zinc. It’s referred to as 'Z-Stack Supplement'.
Related: Best Pulse Oximeter
Eliminate Seed Oils
Eliminate vegetable (seed) oils in your diet, which involves eliminating nearly all processed foods and most meals in restaurants unless you convince the chef to only cook with butter. Avoid any sauces or salad dressings in restaurants as they are loaded with seed oils. Also avoid chicken and pork as they are very high in linoleic acid, the omega-6 fat that is far too high in nearly everyone and contributes to oxidative stress that causes heart disease.
Metabolic Health
The ability to eliminate insulin resistance is a strategy that addresses the majority of illnesses that you will ever encounter in your lifetime.
This is why time-restricted eating, eliminating industrially processed seed oils like soy, corn and canola oils, eating a cyclical ketogenic diet, exercising and sleeping well can improve, if not eliminate, most conditions that you would need to take medications for.
Ivermectin for COVID-19: Real-time meta analysis
Check out the evidence tracking on Ivermectin versus COVID-19 from Ivmmeta.com (constantly updated).
Related: List of Doctors that will prescribe Ivermectin
Notes:
Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs.
Ivermectin is also lipophilic and therefore, bioavailability is maximized on a full stomach; or best to be taken with meal.
Other Potential Treatments
There are over two dozen compounds that have shown effectiveness in treating COVID-19. For a list of COVID-19 early treatment studies, check out c19early.com (constantly updated).
Please check this page regularly for updates – new natural alternatives may be added and/or dose changes to existing alternatives may be made as further scientific studies emerge.
As you can see from the treatment league table above, some of the 'natural alternatives' (including diet (R) and exercise (R)) perform better than synthetic drugs.
Researchers out of India investigated the effects of nigellidine, an indazole alkaloid of black seed, using molecular docking for binding to different angiotensin-binding proteins, as well as the spike glycoprotein. They found that nigellidine "strongly binds" to the spike protein at what is known as the hinge region or active site opening, which may in turn hamper its binding to ACE2 receptor surfaces.
Summary
The combination of quercetin, zinc, vitamin D, vitamin C and melatonin offer a high virus inhibiting and anti-inflammatory potential with a valuable degree of safety at a time of great uncertainty.
That said, based on the above evidence, a combination of vitamin D, quercetin, black seed oil, vitamin A and melatonin might even offer a greater probability of improvement if given as early treatment.
Most clinicians will use the combination approach to get the best outcome. Quercetin, zinc, vitamin D and C are part of the FLCCC's I-CARE protocol and Zelenko Protocol.
Nutrients and supplements are safer alternatives especially if your risk is low e.g. age below 50 and no other chronic illness. Discuss with your doctor on the benefit vs risk for each treatment. If you are on multiple medications, be aware of supplement-drug interactions that might enhance the possibilities of adverse effects.
However, if your risk is high e.g. age above 60, hypertensive, diabetic and obese; you might wish to consult a doctor and discuss more potent alternatives in the FLCCC's I-CARE protocol.
If you review most of the above studies, you will find a very common theme among most of the studies. A key highlight is that 'early treatment' results tend to be better than 'late treatment' results. Therefore, the most important takeaway is to get 'early treatment'. That said, you should never attempt to self medicate without the guidance of a licensed medical provider. If you are not a medical doctor, you are likely to find the information above overwhelming.
Please also follow other precautions and measures (as advised by your local health authorities and doctors) in order to minimize your risk.
Treatments do not replace vaccines and other measures. All practical, effective, and safe means should be used. Elimination is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all variants.
Related:
Doctors Can Prescribe Ivermectin for COVID-19: FDA Lawyer (August 2023)
How Ivermectin Trials Were Designed to Fail (April 2024)
The Last of The "Big Seven" Fraudulent Ivermectin Trials Has Finally Been Published (Mar 2024)
Natural Treatment for Long Haulers
By: Dr Frank Yap, M.D.
I take a product that has Nattokinase and Serrapeptase in the morning on an empty stomach. I didn’t take the shots. I just take it for general health principles.
Thank you very much for this series. Would you please add links to each part of the series?