Nigella sativa aka Black Seed Oil for the Treatment of the covid BioWeapon and Then Some...

Nigella binds to ACE2 receptors in the lungs, potentially stopping spike protein particles from inducing inflammation and vascular damage. The molecule is being studied for possible drug development.

by: 07/27/2021 / Ethan Huff with Natural News

New research published in the journal Vascular Pharmacology shows that a molecule found in Nigella sativa, also known as black seed or black cumin, binds to ACE2 receptors in the lungs, potentially stopping spike protein particles from inducing inflammation and vascular damage. The molecule is being studied for possible drug development.

Researchers out of India investigated the effects of nigellidine, an indazole alkaloid of black seed, using molecular docking for binding to different angiotensin-binding proteins, as well as the spike glycoprotein. They found that nigellidine "strongly binds" to the spike protein at what is known as the hinge region or active site opening, which may in turn hamper its binding to ACE2 receptor surfaces.

"Nigellidine effectively binds in the Angiotensin-II binding site / entry pocket," the study explains. "Nigellidine showed strong binding to mono / multi-meric ACE1."

Nigellidine is being researched as a possible drug candidate that will require further research to understand its full applications in human health.

This process of ACE blocking could, the study goes on to suggest, restore angiotensin levels and restrict vasoturbulence, while the receptor blocking could help to stop resulting inflammation and vascular impairment.

"Nigellidine may slow down the vaso-fluctuations due to Angiotensin deregulations," the paper further explains.

"Angiotensin II-ACE2 binding (ACE-value -294.81) is more favorable than nigellidine-ACE2. Conversely, nigellidine-ACE1 binding-energy / Ki is lower than nigellidine-ACE2 values indicating a balanced-state between constriction-dilatation."

Other research is also being conducted on nigellidine as a candidate for treatment. See this related study, "The Revelation of Various Compounds Found in Nigella sativa L.(Black Cumin) and Their Possibility to Inhibit Infection Based on the Molecular Docking and Physical Properties." (PDF)

As that study explains:

In the present study, using molecular docking, we have identified possible protease inhibitors ... by the molecules present in Nigella sativa L. (black cumin), which is a reputed healing herb extensively used for processing Ayurvedic and Unani remedies. Herein, we perform molecular docking and study of various physical properties/descriptors of four derivatives of thymoquinone found in the essential oil of the said seeds and they are compared with the docking results of chloroquine to determine its potential against ... infection.

Nigellidine may modulate infection, "cytokine storm" through numerous mechanisms

In a related study that was published last year in the journal Europe PMC, researchers learned that nigellidine may potentially inhibit infection in several other ways.

It was discovered early on that some people may suffer "cytokine storms," in which their immune systems are over-responding and causing more damage, or even death.

Nigellidine was then studied and discovered to possess certain properties that may inhibit cytokine storms, as well as impede infection, potentially making it an ideal drug candidate for further research. It is also hepato- and reno-protective, meaning it may help protect against liver and kidney damage.

Beyond this, nigellidine was determined to possess unique immunomodulatory and anti-inflammatory characteristics, as well as antioxidant potential strong enough to inhibit some pathogenic proteins.

In their quest to uncover possible "drug" candidates to protect patients against hyper-inflammation and other associated problems, the researchers learned that nigellidine may helps with preventing negative side effects.

Along with nigellicine, nigellidine is found in the seed coat of Nigella sativa. Both of these constituents in their sulfated forms are extremely bioavailable, and along with thymoquinone and dithymoquinone, two other black seed components, they show strong antioxidant, antibacterial, anti-hypertensive, anti-inflammatory and immunomodulatory effects that may be found useful with further clinical research.

Black seed is also recognized as a metabolic protector, helping to improve lipid and blood sugar levels.

"Vasorelaxant and anti-hypertensive function of [black seed] helps in the modulation of renin angiotensin system (RAS) or the diuretic activity, which is one of the major targets. It might have great protective role during post infective secondary disorder of the peripheral vasculature namely cardiac and renal systems. In most of the instances patients die due to this organ dysfunction/failure," the study says.

By quelling inflammation, nigellidine could help support public health

Other studies have found that intake of Nigella sativa significantly improves the parameters of blood sugar metabolism, as well as glycated hemoglobin.

Based on this, experts believe that nigellidine specifically could play an important role by "docking" to the proteins and inflammatory molecules that can cause a cytokine storm – mainly TNF-? receptors such as TNFR1, TNFR2 and IL1R.

"In the experimental rat model the source of this drug Nigella sativa; black cumin seed extracts were tested for its role on antioxidant, hepatic and renal status," the paper states.

"In the current study, we have decisively shown by molecular modeling that nigellidine can bind in the active sites of several important proteins... several host receptors [for] inflammatory markers IL1, IL6, TNF-?. Moreover, the extract from black cumin seed has been shown in experimental rat to be highly antioxidative, hepato- and reno-protective. Further studies are necessary to verify the potential effects of nigellidine in in vivo laboratory experimental animal model."

Sources for this article

Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

by: PMC

Effects of Active Compounds of Nigella sativa in COVID-19: A Narrative Review

by: PubMed

How the COVID-19 Vaccinated Can Benefit

• antimicrobial against wide variety of bacterial, fungal and parasitic organismsincluding tape worms, hook worms and nodular worms (click here)

  • works against Staph, Salmonella, E.Coli, Shigella, Pseudomonas (click here)

  • works against fungal diseases like Candida and Aspergillosis (click here)

• anti-viral: blocks ACE2 receptors, acts as Zinc ionophore to enhance Zinc entry into cells for anti-viral effects in COVID-19 (click here)

• anti-inflammatory: reduces skin rashes, edema, granuloma formation (click here)

• treats gastrointestinal disorders: anti-ulcer activity, anti-colitis activity (click here)

• anti-hepatotoxicity: protects liver from various toxins (antioxidant effect of thymoquinone) (click here)

• anti-nephrotoxicity: protects kidneys from chemo toxicity, proteinuria, albuminuria, hyperlipidemia with nephrotic syndrome (also antioxidant effect of thymoquinone) (click here)

• treats asthma, bronchospasm and chest congestion (nigellone is the active ingredient that inhibits histamine release from mast cells) (click here)

• treats dyslipidemia: lowers serum cholesterol, triglycerides and glucose (click here)

• anti-diabetic activity (click here)

• analgesic – has potent analgesic effects through opioid receptors

• treatment of multiple sclerosis – thymoquinone shown to have a role (click here)

• anti-cancer activity: thymoquinone has activity against leukemias, breast cancer, colon cancer, pancreatic adenocarcinoma, hepatic cancer, lung cancer, renal cancer, prostate and cervical cancers (click here)

Thank you for sharing Nigella sativa Seed picture above, Rob Endure

by Michael Chamberlain of TeaHow.com

Black seed tea is a herbal tea made from Nigella seeds that is rich in antioxidants, the benefits include lowering cholesterol, combating bacterial strains and chronic conditions, and alleviating inflammation. It is also caffeine-free. It is a natural anticoagulant, it may interact with blood clotting effects and beta-blockers.

Honey acts as a carrier in to body for Nigella sativa.

How to brew black seed tea

• Add the water and the black seeds into a pot and bring to a boil. 

• Remove from the heat once boiled

• Cover the pot and let it steep for 10 minutes 

• Strain the water into a cup using a wire mesh. Some have it along with the seeds to enjoy the whole benefits. 

• Add Sweetener of choice, (Sugar is POISON)

• Serve and enjoy!

Benefits of black seed tea

1. Free from caffeine

As an herbal tea, or infusion, black seed tea is free from caffeine. This makes it a perfect substitute for a cup of tea that you may want to avoid for its caffeine.

Besides, back tea is easily available and is less expensive to make when compared to most other herbal tea varieties, but does of course contain caffeine.

For more about caffeine content in different teas, you can see my other articles explaining the caffeine content for white tea, Chamomile, Peppermint, Earl Grey, Darjeeling, Lotus tea, and matcha tea.

2. Packed with antioxidants

Black seed tea has a higher than usual amount of antioxidants purely from black seeds. These antioxidants can neutralize harmful free radicals and prevents oxidative damages to cells 

3. May prevent chronic conditions

Black seed tea can protect against several types of chronic conditions such as cancer, diabetes, heart diseases, and obesity. Black seed tea in specific favors against pancreatic, lung, cervical, prostate, skin, and colon cancers.

4. Lowers cholesterol

Although cholesterol in some amount is essential to the body, too much cholesterol can increase your risk of heart diseases. Black seed tea can help reduce both total and “bad” LDL cholesterol.

5. Protects against bacterial strains

Black seed tea has antibacterial properties that are effective at fighting off certain strains of bacteria and bacteria-related diseases. Black seed tea also can inhibit the growth of bacteria.

6. Alleviates and suppresses inflammation

In most cases, inflammation is a normal immune response that helps protect the body against injury and infection. Black seed tea can alleviate and suppress inflammation. 

This can be beneficial for cold, flu, and asthma as well. These properties help in treating oxidative stress as well. 

Side effects of black seed tea

Although there are No specific side effects associated with black seed tea, there are a few risks to be aware of. 

Firstly, the component “Melanthin” in black seeds can be toxic in large amounts. 

Secondly, black seed tea may slow blood clotting and increase the risks of bleeding. So if you take medications that affect blood clotting, you can avoid black seed tea or you can temporarily stop your medication while taking Nigella sativa. Nigella sativa is an AntiCoagulant. It naturally thins your body and prevents blood clotting.

Black seed can slow down or stop the uterus from contracting. Black seed tea also interacts with medications such as beta-blockers.

Finally, although black seed tea is safe for pregnant or breast feeding women or among children, consultation with your doctor.

53 Health and Beauty Benefits of Black Seed Oil

by: AllRemedies.com

Where to buy Nigella sativa

Organic Virgin Black Seed Oil
CTFA Name: Black Seed Oil
INCI Name: Nigella Sativa (Organic Black Seed Oil)
COUNTRY OF ORIGIN: Turkey

Organic black seed oil is one of those oils that you should put in every single product you make. There is NOTHING negative about this oil.

Black seed oil is known in the Middle East as the oil that cures everything but death. It comes from the black cumin seed and has been studied and proven to kill skin cancer cells when applied topically, as well as various kinds of cancer when consumed internally.

Where to buy Organic Nigella sativa seeds

Nigella sativa seed for tea sold at StarWestBotanicals.com

by: SWB

Also known as black cumin and kalonji, Nigella seeds have a rich aroma, delicious crunch, and notes of onion, oregano, and black pepper. Nigella seed benefits include providing whole body support and protection.*

Botanical Name: Nigella sativa

Origin: Egypt