Cat's Claw Revolutionizes Care for covid Induced Cognitive Decline? Cat's Claw, reverses cognitive decline and protects brain health, become vital in ensuring the long-term quality of life for us all.
Great consistency, Geneva, in how you are teaching others the great, as yet untapped benefits of Cat's Claw. As the world population faces ever increasing levels of cognitive decline and the premature deaths and suffering associated with dementia, Cat's Claw offers people the chance of making a U turn in their health. The key is that it must be taken in a pure and whole way, not in processed form as you yourself have emphasized. Thank you for showing people how nature can heal people of the terrible trap we find ourselves in today. You are doing a great service to people.
"We have identified one Peruvian source (referred to as “PTI-00703 cat’s claw”) that produces an Uncaria tomentosa extract (dry bark powder) to contain the most robust “plaque” dissolving activity compared to other cat’s claw sources tested (Snow et al., unpublished data)."
Do we have any way of knowing if your recommendation is from this source?
I appreciate that information you're qiven me previously. The quote was extracted from on article on Nature.com, which indicated a particular source for CC which was MOST affective in addressing Brain plaque.
We have identified one Peruvian source (referred to as “PTI-00703 cat’s claw”) that produces an Uncaria tomentosa extract (dry bark powder) to contain the most robust “plaque” dissolving activity compared to other cat’s claw sources tested (Snow et al., unpublished data).
My mother had Alzheimer's for 25 years. I gave her Cat's Claw, it helped slow down the Alzheimer's a bit, but never stopped the Alzheimer's. The BioWeapon only made her Alzheimer's condition worse. The damage was already done by Alzheimer's disease long before I put her on Cat's Claw to detox her from the BioWeapon.
The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles: https://www.nature.com/articles/s41598-019-38645-0
Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that contribute to accelerated memory loss and cognitive decline. In the present investigation we identified a specific plant extract and its constituents as a potential alternative natural solution for preventing and reducing both brain “plaques and tangles”. PTI-00703 cat’s claw (Uncaria tomentosa from a specific Peruvian source), a specific and natural plant extract from the Amazon rain forest, was identified as a potent inhibitor and reducer of both beta-amyloid fibrils (the main component of “plaques”) and tau protein paired helical filaments/fibrils (the main component of “tangles”). PTI-00703 cat’s claw demonstrated both the ability to prevent formation/aggregation and disaggregate preformed Aβ fibrils (1–42 and 1–40) and tau protein tangles/filaments. The disaggregation/dissolution of Aβ fibrils occurred nearly instantly when PTI-00703 cat’s claw and Aβ fibrils were mixed together as shown by a variety of methods including Thioflavin T fluorometry, Congo red staining, Thioflavin S fluorescence and electron microscopy. Sophisticated structural elucidation studies identified the major fractions and specific constituents within PTI-00703 cat’s claw responsible for both the observed “plaque” and “tangle” inhibitory and reducing activity. Specific proanthocyanidins (i.e. epicatechin dimers and variants thereof) are newly identified polyphenolic components within Uncaria tomentosa that possess both “plaque and tangle” reducing and inhibitory activity. One major identified specific polyphenol within PTI-00703 cat’s claw was epicatechin-4β-8-epicatechin (i.e. an epicatechin dimer known as proanthocyanidin B2) that markedly reduced brain plaque load and improved short-term memory in younger and older APP “plaque-producing” (TASD-41) transgenic mice (bearing London and Swedish mutations). Proanthocyanidin B2 was also a potent inhibitor of brain inflammation as shown by reduction in astrocytosis and gliosis in TASD-41 transgenic mice. Blood-brain-barrier studies in Sprague-Dawley rats and CD-1 mice indicated that the major components of PTI-00703 cat’s claw crossed the blood-brain-barrier and entered the brain parenchyma within 2 minutes of being in the blood. The discovery of a natural plant extract from the Amazon rain forest plant (i.e. Uncaria tomentosa or cat’s claw) as both a potent “plaque and tangle” inhibitor and disaggregator is postulated to represent a potential breakthrough for the natural treatment of both normal brain aging and Alzheimer’s disease.
'cat’s claw, (CC) responsible for both the observed “plaque” and “tangle” inhibitory and reducing activity.'
If CC can inhibit and reduce brain plaque and tangles, I believe CC can remove the 'tough' amyloid white scaffolding in veins and arteries with in extremities. I saw CC reduce the size of my mother's legs, back down to normal. She was able to walk again with her walker, with out any pain in her legs.
Memory support has historically been a focus of the cognitive health space, with predominantly older consumers turning to dietary supplements as a way to manage common symptoms of age-related cognitive decline. While many adults do not think about cognitive decline until they begin to experience it, early intervention may be beneficial. According to Alan Snow, PhD, founder and CEO of supplements company Cognitive Clarity Inc. (Edmonds, WA), the reason memory declines as we age is because of the development of plaques and tangles in the brain.
“The plaques look like Swedish meatballs in the brain,” explains Snow. “They consist of a protein called beta-amyloid protein, and they start approximately in your 20s in about 95% of the population, but nobody knows why it’s caused; it’s not genetic.”
He goes on: “Plaques are outside neurons, so they’re in between neurons in the brain. Tangles consist of a protein called tau protein, which is normally a microtubule-associated protein. Something goes awry where the tau protein becomes tangled, kind of looks like dried-up spaghetti in the neuron, and then the neuron actually dies.”
Both plaques and tangles are neurotoxic to the brain, and their development in and between neurons essentially blocks communication to different parts of the brain, impacting memory. Plaques and tangles are responsible for 90% of memory loss that people experience, with inflammation eventually contributing to memory loss even further. Percepta, a dietary supplement developed by Cognitive Clarity and composed of a proprietary cat’s claw and oolong tea extract, has been clinically demonstrated to inhibit both plaques and tangles.1
According to the research published in Scientific Reports in 2019, the proprietary cat’s claw, with its 11-13 major polyphenolic components, not only prevented the formation of plaques and tangles but also reduced existing plaques and tangles. The study identified one particular proanthocyanidin that potently reduced plaque load in “plaque-producing” transgenic mice, which correlated with improvements in short-term memory.
While Snow’s research focuses on cat’s claw, it also sheds some light on the benefits that polyphenol and proanthocyanidin-rich ingredients have on brain health. In fact, Cognitive Clarity also makes a practitioner line of Percepta that contains black currant extract.
“The black currant extract we use contains 25% proanthocyanidins,” Snow explains. “What we found in our work on cat’s claw is that proanthocyanidins, which are epicatechin-dimers, seem to be very important for reducing plaques and tangles, so we did a lot of research and testing, and we identified black currant.”
Of course, as with all ingredients, sourcing and scientific validation are crucial. Snow points out that not all ingredients are created equal. Polyphenol-rich ingredients have been growing in popularity, and as more manufacturers develop products for the brain health market with these ingredients, the best way to differentiate is to offer ingredients backed with clinical research.
Snow’s research also evaluated mice of different ages. “We looked at both younger animals, in which 3% of their cortex were plaques. Then we looked at older animals, in which 10% of their cortex was filled with plaque, and [who] had severe memory loss,” explains Snow. “We were able to reduce plaques in both sets. In younger animals, there was a 70% reduction, and in older animals, there was a 58% reduction.”
Therefore, while older consumers may derive a benefit from supplementation, it may be advantageous to begin supplementation at a younger age. Younger consumers are already beginning to understand how supplements can support their cognitive health in tangible ways.
Groundbreaking Memory Research Shows Amazonian Plant Extract PTI-00703 Cat's Claw as Potent Inhibitor and Reducer of Both Brain Plaques and Tangles
EDMONDS, Washington, March 5, 2019 /PRNewswire/ -- Scientific Reports recently published a landmark research paper which has immediate favorable implications for brain health and memory loss in the aging brain. The paper entitled, "The Amazon rain forest plant Uncaria tomentosa (Cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles," identifies Amazonian rain forest plant extract PTI-00703 Cat's claw as a potent natural solution to inhibit and reduce the accumulation of beta-amyloid plaques and tau protein tangles in the brain, the main reason we lose memory as we age
Thus, our results provide evidence for an antioxidant mechanism underlying the anti-inflammatory activity of cat's claw and support some of the biological effects of proanthocyanidins, more exactly its antioxidant and radical scavenging activities.
Personally I do not agree with the isolation of Cat's Claw compounds. It works best with the human body in it's whole form, as it has for thousands of years for the Rain Forest natives of Peru. Isolation of compounds might lead to unwanted side effects.
Cat’s claw remains a sacred plant among several indigenous Peruvian and Amazonian tribes.
Great consistency, Geneva, in how you are teaching others the great, as yet untapped benefits of Cat's Claw. As the world population faces ever increasing levels of cognitive decline and the premature deaths and suffering associated with dementia, Cat's Claw offers people the chance of making a U turn in their health. The key is that it must be taken in a pure and whole way, not in processed form as you yourself have emphasized. Thank you for showing people how nature can heal people of the terrible trap we find ourselves in today. You are doing a great service to people.
❤️ Thank you Dr. Corrin. You are too kind with your words.
😊👍👍
from Nature.Com
"We have identified one Peruvian source (referred to as “PTI-00703 cat’s claw”) that produces an Uncaria tomentosa extract (dry bark powder) to contain the most robust “plaque” dissolving activity compared to other cat’s claw sources tested (Snow et al., unpublished data)."
Do we have any way of knowing if your recommendation is from this source?
I am not sure I understand your question.
Source meaning where the CC I recommend is from?
I always recommend CC, Uncaria tomentosa, Peruvian CC.
I recommend buying CC from reputable herb companies as follows:
WHOLE WORLD BOTANICALS: https://wholeworldbotanicals.com/products/royal-cats-claw/?variant=49264584458532
Herbco.com: https://www.herbco.com/p-778-cats-claw-bark-cs-wild-crafted.aspx
StarWestBotanicals: https://www.starwest-botanicals.com/product/cats-claw-inner-bark-powder-wildcrafted/
MountainRoseherbs: https://mountainroseherbs.com/cats-claw
Frontier Co-Op: https://www.frontiercoop.com/products/frontier-co-op-cat-s-claw-bark-cut-sifted-1-lb
All have country of origin down as Peru.
Did I answer your question?
I appreciate that information you're qiven me previously. The quote was extracted from on article on Nature.com, which indicated a particular source for CC which was MOST affective in addressing Brain plaque.
again, from Nature.Com
We have identified one Peruvian source (referred to as “PTI-00703 cat’s claw”) that produces an Uncaria tomentosa extract (dry bark powder) to contain the most robust “plaque” dissolving activity compared to other cat’s claw sources tested (Snow et al., unpublished data).
I just found this comment Thaddeus.
My mother had Alzheimer's for 25 years. I gave her Cat's Claw, it helped slow down the Alzheimer's a bit, but never stopped the Alzheimer's. The BioWeapon only made her Alzheimer's condition worse. The damage was already done by Alzheimer's disease long before I put her on Cat's Claw to detox her from the BioWeapon.
The following is by Scientific Reports - nature.com - https://www./articles/s41598-019-38645-0
The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles: https://www.nature.com/articles/s41598-019-38645-0
Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that contribute to accelerated memory loss and cognitive decline. In the present investigation we identified a specific plant extract and its constituents as a potential alternative natural solution for preventing and reducing both brain “plaques and tangles”. PTI-00703 cat’s claw (Uncaria tomentosa from a specific Peruvian source), a specific and natural plant extract from the Amazon rain forest, was identified as a potent inhibitor and reducer of both beta-amyloid fibrils (the main component of “plaques”) and tau protein paired helical filaments/fibrils (the main component of “tangles”). PTI-00703 cat’s claw demonstrated both the ability to prevent formation/aggregation and disaggregate preformed Aβ fibrils (1–42 and 1–40) and tau protein tangles/filaments. The disaggregation/dissolution of Aβ fibrils occurred nearly instantly when PTI-00703 cat’s claw and Aβ fibrils were mixed together as shown by a variety of methods including Thioflavin T fluorometry, Congo red staining, Thioflavin S fluorescence and electron microscopy. Sophisticated structural elucidation studies identified the major fractions and specific constituents within PTI-00703 cat’s claw responsible for both the observed “plaque” and “tangle” inhibitory and reducing activity. Specific proanthocyanidins (i.e. epicatechin dimers and variants thereof) are newly identified polyphenolic components within Uncaria tomentosa that possess both “plaque and tangle” reducing and inhibitory activity. One major identified specific polyphenol within PTI-00703 cat’s claw was epicatechin-4β-8-epicatechin (i.e. an epicatechin dimer known as proanthocyanidin B2) that markedly reduced brain plaque load and improved short-term memory in younger and older APP “plaque-producing” (TASD-41) transgenic mice (bearing London and Swedish mutations). Proanthocyanidin B2 was also a potent inhibitor of brain inflammation as shown by reduction in astrocytosis and gliosis in TASD-41 transgenic mice. Blood-brain-barrier studies in Sprague-Dawley rats and CD-1 mice indicated that the major components of PTI-00703 cat’s claw crossed the blood-brain-barrier and entered the brain parenchyma within 2 minutes of being in the blood. The discovery of a natural plant extract from the Amazon rain forest plant (i.e. Uncaria tomentosa or cat’s claw) as both a potent “plaque and tangle” inhibitor and disaggregator is postulated to represent a potential breakthrough for the natural treatment of both normal brain aging and Alzheimer’s disease.
OK, I've found another link mentioning PTI-00703 cat's claw (Uncaria tomentosa from a specific Peruvian source), but PT1-00703 remains a mystery
https://pubmed.ncbi.nlm.nih.gov/30728442/
I'll keep my eyes open should I come up on any more information.
'cat’s claw, (CC) responsible for both the observed “plaque” and “tangle” inhibitory and reducing activity.'
If CC can inhibit and reduce brain plaque and tangles, I believe CC can remove the 'tough' amyloid white scaffolding in veins and arteries with in extremities. I saw CC reduce the size of my mother's legs, back down to normal. She was able to walk again with her walker, with out any pain in her legs.
My internet is in and out today because of a snow storm. I did not get a chance to read these articles. Hopefully they lead to answers.
PDF
PTI-00703 https://www.alzdiscovery.org/uploads/cognitive_vitality_media/PTI-00703-Cognitive-Vitality-For-Researchers.pdf
proanthocyanidin ?
Memory support has historically been a focus of the cognitive health space, with predominantly older consumers turning to dietary supplements as a way to manage common symptoms of age-related cognitive decline. While many adults do not think about cognitive decline until they begin to experience it, early intervention may be beneficial. According to Alan Snow, PhD, founder and CEO of supplements company Cognitive Clarity Inc. (Edmonds, WA), the reason memory declines as we age is because of the development of plaques and tangles in the brain.
“The plaques look like Swedish meatballs in the brain,” explains Snow. “They consist of a protein called beta-amyloid protein, and they start approximately in your 20s in about 95% of the population, but nobody knows why it’s caused; it’s not genetic.”
He goes on: “Plaques are outside neurons, so they’re in between neurons in the brain. Tangles consist of a protein called tau protein, which is normally a microtubule-associated protein. Something goes awry where the tau protein becomes tangled, kind of looks like dried-up spaghetti in the neuron, and then the neuron actually dies.”
Both plaques and tangles are neurotoxic to the brain, and their development in and between neurons essentially blocks communication to different parts of the brain, impacting memory. Plaques and tangles are responsible for 90% of memory loss that people experience, with inflammation eventually contributing to memory loss even further. Percepta, a dietary supplement developed by Cognitive Clarity and composed of a proprietary cat’s claw and oolong tea extract, has been clinically demonstrated to inhibit both plaques and tangles.1
According to the research published in Scientific Reports in 2019, the proprietary cat’s claw, with its 11-13 major polyphenolic components, not only prevented the formation of plaques and tangles but also reduced existing plaques and tangles. The study identified one particular proanthocyanidin that potently reduced plaque load in “plaque-producing” transgenic mice, which correlated with improvements in short-term memory.
While Snow’s research focuses on cat’s claw, it also sheds some light on the benefits that polyphenol and proanthocyanidin-rich ingredients have on brain health. In fact, Cognitive Clarity also makes a practitioner line of Percepta that contains black currant extract.
“The black currant extract we use contains 25% proanthocyanidins,” Snow explains. “What we found in our work on cat’s claw is that proanthocyanidins, which are epicatechin-dimers, seem to be very important for reducing plaques and tangles, so we did a lot of research and testing, and we identified black currant.”
Of course, as with all ingredients, sourcing and scientific validation are crucial. Snow points out that not all ingredients are created equal. Polyphenol-rich ingredients have been growing in popularity, and as more manufacturers develop products for the brain health market with these ingredients, the best way to differentiate is to offer ingredients backed with clinical research.
Snow’s research also evaluated mice of different ages. “We looked at both younger animals, in which 3% of their cortex were plaques. Then we looked at older animals, in which 10% of their cortex was filled with plaque, and [who] had severe memory loss,” explains Snow. “We were able to reduce plaques in both sets. In younger animals, there was a 70% reduction, and in older animals, there was a 58% reduction.”
Therefore, while older consumers may derive a benefit from supplementation, it may be advantageous to begin supplementation at a younger age. Younger consumers are already beginning to understand how supplements can support their cognitive health in tangible ways.
Groundbreaking Memory Research Shows Amazonian Plant Extract PTI-00703 Cat's Claw as Potent Inhibitor and Reducer of Both Brain Plaques and Tangles
EDMONDS, Washington, March 5, 2019 /PRNewswire/ -- Scientific Reports recently published a landmark research paper which has immediate favorable implications for brain health and memory loss in the aging brain. The paper entitled, "The Amazon rain forest plant Uncaria tomentosa (Cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles," identifies Amazonian rain forest plant extract PTI-00703 Cat's claw as a potent natural solution to inhibit and reduce the accumulation of beta-amyloid plaques and tau protein tangles in the brain, the main reason we lose memory as we age
https://markets.businessinsider.com/news/stocks/groundbreaking-memory-research-shows-amazonian-plant-extract-pti-00703-cat-s-claw-as-potent-inhibitor-and-reducer-of-both-brain-plaques-and-tangles-1028006971
Cat’s claw - https://nurservicio.com/cats-claw-2/
Cat's Claw – Proanthocyanidins ( Proanthocyanidin C1, Epiafzelechin-4Beta-8, Proanthocyanidin B4, Proanthocyanidin B2, Epicatechin, Chlorogenic acid) (4)
Proanthocyanidins: https://raysahelian.com/proanthocyanidins.html
Thus, our results provide evidence for an antioxidant mechanism underlying the anti-inflammatory activity of cat's claw and support some of the biological effects of proanthocyanidins, more exactly its antioxidant and radical scavenging activities.
Personally I do not agree with the isolation of Cat's Claw compounds. It works best with the human body in it's whole form, as it has for thousands of years for the Rain Forest natives of Peru. Isolation of compounds might lead to unwanted side effects.
Cat’s claw remains a sacred plant among several indigenous Peruvian and Amazonian tribes.
https://www.casi.org/node/889
Cat’s Claw Spiritual Benefits: Remove Negative Energy! https://spiritualdesk.com/cats-claw-spiritual-benefits/
That's a wonderful find! Have you derived similar benefits from CC?